With cars, come from Rome on E45, passing through Orte, or come from Bologna passing through Cesena, or from Florence on A1, exiting at Bettolle in direction of Perugia.

With the train, visit italian trains schedule web site www.trenitalia.it.

With the plane, you can reach Fiumicino (Rome) and then come by train or by plane to the close Sant'Egidio airport,
10 km from Assisi.